Article
Tumorigenic and mitogenic capacities are reduced in transfected fibroblasts expressing mutant insulin-like growth factor (IGF)-I receptors. The role of tyrosine residues 1250, 1251, and 1316 in the carboxy-terminus of the IGF-I receptor.
Endocrinology - 1 Feb 1996
Blakesley V A, Kalebic T, Helman L J, Stannard B, Faria T N, Roberts C T, LeRoith D
Abstract excerpt
Regulation of ligand-mediated signal transduction through transmembrane tyrosine kinase growth factor receptors involves phosphorylation of tyrosine residues in the intracellular domain of the receptor. The insulin-like growth factor-I (IGF-I) receptor contains three tyrosine residues in the carb...
Topics
- 3T3 Cells
- Animals
- Base Sequence
- Fibroblasts
- Humans
- Insulin-Like Growth Factor I
- Mice
- Mice, Nude
- Mitosis
- Molecular Sequence Data
- Mutation
- Neoplasms, Experimental
- Peptide Fragments
- Phosphorylation