Article
Cooperative regulation of the invasive and metastatic phenotypes by different domains of the type I insulin-like growth factor receptor beta subunit.
The Journal of biological chemistry - 7 Sept 2001
Brodt P, Fallavollita L, Khatib A M, Samani A A, Zhang D
Abstract excerpt
The receptor for the type 1 insulin-like growth factor (IGF-I) regulates multiple cellular functions impacting on the metastatic phenotype of tumor cells, including cellular proliferation, anchorage-independent growth, survival, migration, synthesis of the 72-kDa type IV collagenase and invasion. We have used site-directed mutagenesis to generate domain-specific mutants of the receptor beta subunit to analyze the...
Topics
- Cell Movement
- Cloning, Molecular
- DNA Mutational Analysis
- DNA, Complementary
- Dose-Response Relationship, Drug
- Gene Expression Regulation, Neoplastic
- Genes, Dominant
- Humans
- Insulin-Like Growth Factor I
- Kinetics
- Matrix Metalloproteinase 2
- Mutagenesis, Site-Directed