Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypothesis: a memory lymphocyte-specific soma-to-germline genetic feedback loop.

Immunology and cell biology - 1 Apr 1995

Rothenfluh H S

Abstract excerpt

Analysis of recently published DNA sequence data obtained for related germline Ig variable (IgV) genetic elements of several vertebrate species revealed the presence of a number of extremely non-random patterns of sequence variability among these genes. Strikingly, the patterns were also observed in two sets of chicken IgV pseudogenes. Since the observed patterns are clearly incompatible with existing theories of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Conserved Sequence
Share to Genetic Vectors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lymphocytes

Share to Models, Genetic

Share to Mutation

Share to Rabbits

Source

Identifiers

PMID: 7797237
DOI: 10.1038/icb.1995.28

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypothesis: a memory lymphocyte-specific soma-to-germline genetic feedback loop.PMID 7797237Read ↗

Soma‐to‐germline feedback is implied by the extreme polymorphism at IGHV relative to MHCSemantic proximity Read ↗

A model of the early evolution of soma-to-germline feedback.Semantic proximity Read ↗

Somatic hypermutation: mutations 3' of rabbit VDJ H-chain genes.Semantic proximity Read ↗

The signature of somatic hypermutation appears to be written into the germline IgV segment repertoire.Semantic proximity Read ↗

A unifying hypothesis for the molecular mechanism of somatic mutation and gene conversion in rearranged immunoglobulin variable genes.Semantic proximity Read ↗

Somatic generation of diversity in a mammalian primary lymphoid organ: the sheep ileal Peyer's patches.Semantic proximity Read ↗

Origin and maintenance of germ-line V genes.Semantic proximity Read ↗

Somatic diversification of chicken immunoglobulin light chains by point mutations.Semantic proximity Read ↗

Somatic mutations during an immune response in Xenopus tadpoles.Semantic proximity Read ↗

Gene-conversion in rabbit B-cell ontogeny and during immune responses in splenic germinal centers.Semantic proximity Read ↗

Germ line maintenance of the pseudogene donor pool for somatic immunoglobulin gene conversion in chickens.Semantic proximity Read ↗

Stochastic rearrangement of immunoglobulin variable-region genes in chicken B-cell development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.