Hypothesis: a memory lymphocyte-specific soma-to-germline genetic feedback loop.

doi:10.1038/icb.1995.28

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Article

Hypothesis: a memory lymphocyte-specific soma-to-germline genetic feedback loop.

Immunology and cell biology - 1 Apr 1995

Rothenfluh H S

Abstract excerpt

Analysis of recently published DNA sequence data obtained for related germline Ig variable (IgV) genetic elements of several vertebrate species revealed the presence of a number of extremely non-random patterns of sequence variability among these genes. Strikingly, the patterns were also observed...

Topics

Animals
Antibody Diversity
Base Sequence
Conserved Sequence
Feedback
Genes, Immunoglobulin
Genetic Vectors
Immunoglobulin Variable Region
Immunologic Memory
Lymphocytes
Male
Mice
Models, Genetic
Mutation
Rabbits
Retroviridae

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