Article
Somatic diversification of chicken immunoglobulin light chains by point mutations.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1990
Parvari R, Ziv E, Lantner F, Heller D, Schechter I
Abstract excerpt
The light-chain locus of chicken has 1 functional V lambda 1 gene, 1 J gene, and 25 pseudo-V lambda-genes (where V = variable and J = joining). A major problem is which somatic mechanisms expand this extremely limited germ-line information to generate many different antibodies. Weill's group [Rey...
Topics
- Animals
- Base Sequence
- Chickens
- Codon
- Gene Conversion
- Gene Rearrangement
- Genetic Variation
- Immunoglobulin Joining Region
- Immunoglobulin Light Chains
- Introns
- Molecular Sequence Data
- Mutation