Article
Somatic generation of diversity in a mammalian primary lymphoid organ: the sheep ileal Peyer's patches.
Cell - 8 Mar 1991
Reynaud C A, Mackay C R, Müller R G, Weill J C
Abstract excerpt
Ileal Peyer's patches (IPPs) in the sheep are composed of tightly packed follicles in which surface IgM-positive B cells proliferate and can be exported to the periphery. We report that the light chain rearrangement pattern in a single IPP follicle is much more restricted than in the entire tissue, which indicates that, as in the chicken bursa, ongoing rearrangement does not take place in this organ. Moreover, we...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular
- DNA
- Genetic Variation
- Ileum
- Immunoglobulin Light Chains
- Immunoglobulin Variable Region
- Introns
- Molecular Sequence Data