A unifying hypothesis for the molecular mechanism of somatic mutation and gene conversion in rearranged immunoglobulin variable genes.

doi:10.1046/j.1440-1711.1998.00738.x

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Article

A unifying hypothesis for the molecular mechanism of somatic mutation and gene conversion in rearranged immunoglobulin variable genes.

Immunology and cell biology - 1 Jun 1998

Blanden R V, Steele E J

Abstract excerpt

We have reviewed available data concerning the mechanism of somatic hypermutation in rearranged variable genes of Ig in B lymphocytes of mice and the gene conversion process which generates diversity in these genes in the B lymphocytes of chickens. In our view, these data are consistent with a unifying hypothesis of diversity generating mechanisms involving reverse transcription to produce cDNA from RNA...

Topics

Animals
Gene Conversion
Gene Rearrangement, B-Lymphocyte
Immunoglobulin Variable Region
Models, Biological
Models, Chemical
Mutation

Source

Open in PubMed

Identifiers

PMID: 9682973
DOI: 10.1046/j.1440-1711.1998.00738.x

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