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Article

Germ line maintenance of the pseudogene donor pool for somatic immunoglobulin gene conversion in chickens.

Molecular and cellular biology - 1 Feb 1993

McCormack W T, Hurley E A, Thompson C B

Abstract excerpt

Somatic immunoglobulin diversity is generated in avian species by sequential gene conversion of variable (V) gene segments of the immunoglobulin heavy- and light-chain loci during B-cell development. The germ line pools of donor sequence information for somatic V-region gene conversion are found in families of V pseudogenes, located 5' of the single functional V gene of each locus. The sequence relationships...

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Identifiers

PMID: 8423804
DOI: 10.1128/mcb.13.2.821-830.1993
PMCID: PMC358965

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