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Article

Somatic mutations during an immune response in Xenopus tadpoles.

Developmental immunology - 1 Jan 1995

Wilson M, Marcuz A, du Pasquier L

Abstract excerpt

The tadpole B-cell repertoire is less diverse than that of the adult frog; their antibodies are of lower affinity and are less heterogenous. In order to determine whether this difference is due to a lack of or a reduced rate of somatic hypermutation, we analyzed and compared cDNA sequences utilizing VH1 elements with germline counterparts in isogenic LG7 tadpoles during an immune response. Indeed, tadpole VH1...

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Identifiers

PMID: 8770561
DOI: 10.1155/1995/38639
PMCID: PMC2275958

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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