Article
Somatic mutations during an immune response in Xenopus tadpoles.
Developmental immunology - 1 Jan 1995
Wilson M, Marcuz A, du Pasquier L
Abstract excerpt
The tadpole B-cell repertoire is less diverse than that of the adult frog; their antibodies are of lower affinity and are less heterogenous. In order to determine whether this difference is due to a lack of or a reduced rate of somatic hypermutation, we analyzed and compared cDNA sequences utiliz...
Topics
- Animals
- B-Lymphocytes
- Base Sequence
- DNA, Complementary
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Genes, Immunoglobulin
- Larva
- Molecular Sequence Data
- Mutation
- Sequence Homology, Nucleic Acid
- Xenopus
- Xenopus laevis