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Article

Origin and maintenance of germ-line V genes.

Immunology and cell biology - 1 Jun 1993

Rothenfluh H S, Steele E J

Abstract excerpt

The distribution of nucleotide variability within the upstream of germ-line VH186.2-related variable genes was studied. The data in this report of work in progress indicate non-random selection for variability in the second antigen-contact or complementarity-determining region (CDR2) for 12 such genes isolated using the polymerase chain reaction (PCR) technique from genomic C57BL/6 mouse liver DNA. The translated...

Topics

Animals
Base Sequence
Genes, Immunoglobulin
Genetic Variation
Immunoglobulin Variable Region
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Phylogeny
Polymerase Chain Reaction
Selection, Genetic

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Source

Identifiers

PMID: 8349306
DOI: 10.1038/icb.1993.26

Genes

CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8349306-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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