Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Stochastic rearrangement of immunoglobulin variable-region genes in chicken B-cell development.

Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 1992

Benatar T, Tkalec L, Ratcliffe M J

Abstract excerpt

The molecular mechanism by which immunoglobulin (Ig) gene rearrangement occurs is highly conserved between mammalian and avian species. However, in avian species, an equivalent to the mammalian pre-B cell, which has undergone Ig heavy-chain gene rearrangement and expresses mu heavy chains in the absence of Ig light-chain rearrangement, has not been convincingly demonstrated. It is consequently unclear whether an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to B-Lymphocytes
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Blotting, Southern

Share to Cloning, Molecular

Share to Molecular Sequence Data

Share to Oligodeoxyribonucleotides

Source

Open in PubMed Open full text

Identifiers

PMID: 1502173
DOI: 10.1073/pnas.89.16.7615
PMCID: PMC49761

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Stochastic rearrangement of immunoglobulin variable-region genes in chicken B-cell development.PMID 1502173Read ↗

Rearrangement of immunoglobulin genes in chicken B cell development.Semantic proximity Read ↗

Development of B cells expressing surface immunoglobulin molecules that lack V(D)J-encoded determinants in the avian embryo bursa of FabriciusSemantic proximity Read ↗

Avian B-Cell Development: Generation of an Immunoglobulin Repertoire by Gene ConversionSemantic proximity Read ↗

The v-rel oncogene of avian reticuloendotheliosis virus transforms immature and mature lymphoid cells of the B cell lineage in vitro.Semantic proximity Read ↗

Somatic diversification of chicken immunoglobulin light chains by point mutations.Semantic proximity Read ↗

Bursectomy of chicken embryos at 60 hours of incubation leads to an oligoclonal B cell compartment and restricted Ig diversity.Semantic proximity Read ↗

B-cell development in the amphibian Xenopus.Semantic proximity Read ↗

Rearrangement-enhancing element upstream of the mouse immunoglobulin kappa chain J cluster.Semantic proximity Read ↗

Immunoglobulin gene conversion: insights from bursal B cells and the DT40 cell line.Semantic proximity Read ↗

The chicken B-cell receptor complex and its role in avian B-cell development.Semantic proximity Read ↗

Comparative architectures of mammalian and chicken genomes reveal highly variable rates of genomic rearrangements across different lineages.Semantic proximity Read ↗

Gene-conversion in rabbit B-cell ontogeny and during immune responses in splenic germinal centers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.