Article
Stochastic rearrangement of immunoglobulin variable-region genes in chicken B-cell development.
Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 1992
Benatar T, Tkalec L, Ratcliffe M J
Abstract excerpt
The molecular mechanism by which immunoglobulin (Ig) gene rearrangement occurs is highly conserved between mammalian and avian species. However, in avian species, an equivalent to the mammalian pre-B cell, which has undergone Ig heavy-chain gene rearrangement and expresses mu heavy chains in the absence of Ig light-chain rearrangement, has not been convincingly demonstrated. It is consequently unclear whether an...
Topics
- Alleles
- Animals
- B-Lymphocytes
- Base Sequence
- Blotting, Southern
- Bursa of Fabricius
- Cell Transformation, Viral
- Chick Embryo
- Chickens
- Cloning, Molecular
- DNA