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Article

A model of the early evolution of soma-to-germline feedback.

Journal of theoretical biology - 7 May 2002

Zhivotovsky Lev A

Abstract excerpt

The V-genes of the immunoglobulin locus in vertebrates code for a part of the heavy and light chain variable regions of antibodies and are extremely variable. Steele (1979) has developed a theory that explains the evolution of adaptive immune response by a soma-to-germline flow of cDNAs derived from somatically mutated V-genes. Here we model the early evolution of soma-to-germline feedback in a population living...

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Identifiers

PMID: 12076127
DOI: 10.1006/jtbi.2002.2533

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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