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Article

Insulin receptor substrate-1 gene mutations in NIDDM; implications for the study of polygenic disease.

Diabetologia - 1 Apr 1995

Hitman G A, Hawrami K, McCarthy M I, Viswanathan M, Snehalatha C, Ramachandran A, Tuomilehto J, Tuomilehto-Wolf E, Nissinen A, Pedersen O

Abstract excerpt

Variations in the coding regions of the insulin receptor substrate-1 (IRS-1) gene have recently been suggested to contribute to the susceptibility of non-insulin-dependent diabetes mellitus (NIDDM). The purpose of this study was to examine the role of the IRS-1 missense mutations at codons 972 (glycine to arginine) and 513 (alanine to proline) in two diverse populations from South India and Finland at high risk...

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PMID: 7796990
DOI: 10.1007/BF00410287

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Insulin receptor substrate-1 gene mutations in NIDDM; implications for the study of polygenic disease.PMID 7796990Read ↗

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The mutation of insulin receptor substrate-1 gene in Chinese patients with non-insulin-dependent diabetes mellitus.Semantic proximity Read ↗

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