Insulin receptor substrate-1 gene mutations in NIDDM; implications for the study of polygenic disease.

doi:10.1007/BF00410287

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Article

Insulin receptor substrate-1 gene mutations in NIDDM; implications for the study of polygenic disease.

Diabetologia - 1 Apr 1995

Hitman G A, Hawrami K, McCarthy M I, Viswanathan M, Snehalatha C, Ramachandran A, Tuomilehto J, Tuomilehto-Wolf E, Nissinen A, Pedersen O

Abstract excerpt

Variations in the coding regions of the insulin receptor substrate-1 (IRS-1) gene have recently been suggested to contribute to the susceptibility of non-insulin-dependent diabetes mellitus (NIDDM). The purpose of this study was to examine the role of the IRS-1 missense mutations at codons 972 (g...

Topics

Adult
Aged
Alanine
Arginine
Base Sequence
Case-Control Studies
Codon
DNA Primers
Deoxyribonucleases, Type II Site-Specific
Diabetes Mellitus, Type 2
Female
Finland

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Glycine

Humans

India

Insulin Receptor Substrate Proteins

Male

Source

Open in PubMed

Identifiers

PMID: 7796990
DOI: 10.1007/BF00410287

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7796990-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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