Article
UKPDS 19: heterogeneity in NIDDM: separate contributions of IRS-1 and beta 3-adrenergic-receptor mutations to insulin resistance and obesity respectively with no evidence for glycogen synthase gene mutations. UK Prospective Diabetes Study.
Diabetologia - 1 Dec 1996
Zhang Y, Wat N, Stratton I M, Warren-Perry M G, Orho M, Groop L, Turner R C
Abstract excerpt
Insulin receptor substrate-1 (IRS-1), beta 3-adrenergic-receptor (beta 3-AR) and glycogen synthase (GS) genes are candidate genes for non-insulin-dependent diabetes mellitus (NIDDM), insulin resistance, dyslipidaemia and obesity. We studied white Caucasian subjects with NIDDM, 227 being randomly...
Topics
- Adult
- Alleles
- Base Sequence
- Cohort Studies
- DNA Primers
- Diabetes Mellitus, Type 2
- Glycogen Synthase
- Humans
- Hyperlipidemias
- Insulin Receptor Substrate Proteins
- Insulin Resistance
- Lipoprotein Lipase
- Middle Aged
- Mutation