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Molecular scanning for mutations in the insulin receptor substrate-1 (IRS-1) gene in Mexican Americans with Type 2 diabetes mellitus.

Diabetes/metabolism research and reviews - 1 Jan 2000

Celi F S, Negri C, Tanner K, Raben N, De Pablo F, Rovira A, Pallardo L F, Martin-Vaquero P, Stern M P, Mitchell B D, Shuldiner A R

Abstract excerpt

BACKGROUND: Insulin receptor substrate-1 (IRS-1) is an endogenous substrate for the insulin receptor tyrosine kinase, which plays an important role in insulin signaling. Mutations in the IRS-1 gene are associated in some populations with obesity and Type 2 diabetes. METHODS: To determine whether variation in the IRS-1 gene contributes to genetic susceptibility to insulin resistance and Type 2 diabetes in Mexican...

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Identifiers

PMID: 11025561
DOI: 10.1002/1520-7560(2000)9999:9999<::aid-dmrr129>3.0.co;2-b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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