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Article

Insulin receptor substrate-1 variants in non-insulin-dependent diabetes.

The Journal of clinical investigation - 1 Sept 1994

Laakso M, Malkki M, Kekäläinen P, Kuusisto J, Deeb S S

Abstract excerpt

Insulin receptor substrate-1 (IRS-1) plays an important role in insulin-stimulated signaling mechanisms. Therefore, we investigated the frequency and clinical significance of variants in the coding region of this gene in patients with non-insulin-dependent diabetes (NIDDM). Initial screening included a population-based sample of 40 Finnish patients with typical NIDDM. Applying single strand conformation...

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Identifiers

PMID: 8083355
DOI: 10.1172/JCI117429
PMCID: PMC295183

Genes

GRB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Insulin receptor substrate-1 variants in non-insulin-dependent diabetes.PMID 8083355Read ↗

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