Insulin receptor substrate-1 variants in non-insulin-dependent diabetes.

doi:10.1172/JCI117429

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Insulin receptor substrate-1 variants in non-insulin-dependent diabetes.

The Journal of clinical investigation - 1 Sept 1994

Laakso M, Malkki M, Kekäläinen P, Kuusisto J, Deeb S S

Abstract excerpt

Insulin receptor substrate-1 (IRS-1) plays an important role in insulin-stimulated signaling mechanisms. Therefore, we investigated the frequency and clinical significance of variants in the coding region of this gene in patients with non-insulin-dependent diabetes (NIDDM). Initial screening included a population-based sample of 40 Finnish patients with typical NIDDM. Applying single strand conformation...

Topics

Aged
Amino Acid Sequence
Base Sequence
DNA Primers
Diabetes Mellitus, Type 2
Female
Genetic Variation
Glucose Clamp Technique
Humans
Infusions, Intravenous
Insulin
Insulin Receptor Substrate Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Molecular Sequence Data

Phosphoproteins

Point Mutation

Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 8083355
DOI: 10.1172/JCI117429
PMCID: PMC295183

Genes

GRB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8083355-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insulin receptor substrate-1 variants in non-insulin-dependent diabetes.PMID 8083355Read ↗

Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Variant sequences of insulin receptor substrate-1 in patients with noninsulin-dependent diabetes mellitus.Semantic proximity Read ↗

Expression of variant forms of insulin receptor substrate-1 identified in patients with noninsulin-dependent diabetes mellitus.Semantic proximity Read ↗

Novel allele of the insulin receptor substrate-1 bearing two non-conservative amino acid substitutions in a patient with noninsulin-dependent diabetes mellitus. Mutations in brief no. 130. Online.Semantic proximity Read ↗

Association testing of common variants in the insulin receptor substrate-1 gene (IRS1) with type 2 diabetes.Semantic proximity Read ↗

Human insulin receptor substrate-1: variant sequences in familial non-insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Molecular scanning for mutations in the insulin receptor substrate-1 (IRS-1) gene in Mexican Americans with Type 2 diabetes mellitus.Semantic proximity Read ↗

The Gly-->Arg972 amino acid polymorphism in insulin receptor substrate-1 affects glucose metabolism in skeletal muscle cells.Semantic proximity Read ↗

Genetic variants of insulin receptor substrate-1 (IRS-1) in syndromes of severe insulin resistance. Functional analysis of Ala513Pro and Gly1158Glu IRS-1.Semantic proximity Read ↗

Lack of association between the insulin receptor substrates-1 Gly972Arg polymorphism and type-2 diabetes mellitus among Saudis from Eastern Saudi Arabia.Semantic proximity Read ↗

Gly972Arg variant in the insulin receptor substrate-1 gene and association with Type 2 diabetes: a meta-analysis of 27 studies.Semantic proximity Read ↗

The insulin receptor substrate-1 Gly972Arg polymorphism is not associated with Type 2 diabetes mellitus in two population-based studies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.