Article
The Gly972-->Arg IRS-1 variant is associated with type 1 diabetes in continental Italy.
Diabetes - 1 Mar 2003
Federici Massimo, Petrone Antonio, Porzio Ottavia, Bizzarri Carla, Lauro Davide, D'Alfonso Rossella, Patera Ippolita, Cappa Marco, Nisticò Lorenza, Baroni Marco, Sesti Giorgio, di Mario Umberto, Lauro Renato, Buzzetti Raffaella
Abstract excerpt
The Arg(972) insulin receptor substrate-1 (IRS-1) variant has been hypothesized to play a role in pancreatic beta-cell stimulus-coupled insulin secretion and survival. We analyzed the relations between type 1 diabetes and the Arg(972) IRS-1 variant. The frequency of the IRS-1 Arg(972) variant was investigated in two independent sets of unrelated patients: a case-control study and a collection of type 1 diabetes...
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