Article
Human insulin receptor substrate-1: variant sequences in familial non-insulin-dependent diabetes mellitus.
Diabetic medicine : a journal of the British Diabetic Association - 1 Feb 1996
Armstrong M, Haldane F, Taylor R W, Humphriss D, Berrish T, Stewart M W, Turnbull D M, Alberti K G, Walker M
Abstract excerpt
The aetiology of NIDDM is uncertain, although family and twin studies indicate an important role for genetic factors in disease onset. The function and position of IRS-1 within the insulin signalling pathway make it a prime candidate gene for the development of insulin resistance and NIDDM. Insul...
Topics
- Base Sequence
- Diabetes Mellitus, Type 2
- Female
- Humans
- Insulin Receptor Substrate Proteins
- Insulin Resistance
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Pedigree
- Phosphoproteins
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational