Article
Human insulin receptor substrate-1: variant sequences in familial non-insulin-dependent diabetes mellitus.
Diabetic medicine : a journal of the British Diabetic Association - 1 Feb 1996
Armstrong M, Haldane F, Taylor R W, Humphriss D, Berrish T, Stewart M W, Turnbull D M, Alberti K G, Walker M
Abstract excerpt
The aetiology of NIDDM is uncertain, although family and twin studies indicate an important role for genetic factors in disease onset. The function and position of IRS-1 within the insulin signalling pathway make it a prime candidate gene for the development of insulin resistance and NIDDM. Insulin resistant families were identified by studying unaffected first degree relatives from families with 2 or more living...
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