Article
A common mutation of the insulin receptor substrate-1 gene is a risk factor for coronary artery disease.
Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 1999
Baroni M G, D'Andrea M P, Montali A, Pannitteri G, Barillà F, Campagna F, Mazzei E, Lovari S, Seccareccia F, Campa P P, Ricci G, Pozzilli P, Urbinati G, Arca M
Abstract excerpt
Insulin resistance is associated with increased risk of atherosclerosis. Insulin receptor substrate-1 (IRS-1) plays a key role in tissue insulin sensitivity. A common mutation (G972R) of the IRS-1 gene has been shown to impair IRS-1 function, and it has been associated with reduced insulin sensitivity and lipid abnormalities. This led us to investigate the role of the G972R mutation in predisposing individuals to...
Topics
- Adult
- Aged
- Coronary Disease
- Female
- Gene Frequency
- Genetic Markers
- Genetic Predisposition to Disease
- Genetic Variation
- Genotype
- Humans
- Hyperlipidemias
- Insulin Receptor Substrate Proteins
- Insulin Resistance