Article
A common mutation of the insulin receptor substrate-1 gene is a risk factor for coronary artery disease.
Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 1999
Baroni M G, D'Andrea M P, Montali A, Pannitteri G, Barillà F, Campagna F, Mazzei E, Lovari S, Seccareccia F, Campa P P, Ricci G, Pozzilli P, Urbinati G, Arca M
Abstract excerpt
Insulin resistance is associated with increased risk of atherosclerosis. Insulin receptor substrate-1 (IRS-1) plays a key role in tissue insulin sensitivity. A common mutation (G972R) of the IRS-1 gene has been shown to impair IRS-1 function, and it has been associated with reduced insulin sensitivity and lipid abnormalities. This led us to investigate the role of the G972R mutation in predisposing individuals to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.