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Article

Variant sequences of insulin receptor substrate-1 in patients with noninsulin-dependent diabetes mellitus.

The Journal of clinical endocrinology and metabolism - 1 Dec 1994

Imai Y, Fusco A, Suzuki Y, Lesniak M A, D'Alfonso R, Sesti G, Bertoli A, Lauro R, Accili D, Taylor S I

Abstract excerpt

The pathophysiology of noninsulin-dependent diabetes mellitus (NIDDM) is characterized by insulin resistance and insulin deficiency. To search for genetic defects causing NIDDM, we have screened for mutations in the gene encoding insulin receptor substrate-1 (IRS-1), an intracellular protein that is phosphorylated by the insulin receptor and is thought to play an important role in mediating insulin action. The...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 7989470
DOI: 10.1210/jcem.79.6.7989470

Genes

GCA
GCG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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