Article
Variant sequences of insulin receptor substrate-1 in patients with noninsulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism - 1 Dec 1994
Imai Y, Fusco A, Suzuki Y, Lesniak M A, D'Alfonso R, Sesti G, Bertoli A, Lauro R, Accili D, Taylor S I
Abstract excerpt
The pathophysiology of noninsulin-dependent diabetes mellitus (NIDDM) is characterized by insulin resistance and insulin deficiency. To search for genetic defects causing NIDDM, we have screened for mutations in the gene encoding insulin receptor substrate-1 (IRS-1), an intracellular protein that...
Topics
- Adult
- Aged
- Base Sequence
- DNA
- DNA Mutational Analysis
- Diabetes Mellitus, Type 2
- Female
- Humans
- Insulin Receptor Substrate Proteins
- Male
- Middle Aged
- Mutation
- Obesity
- Phosphoproteins
- Polymerase Chain Reaction