The mutation of insulin receptor substrate-1 gene in Chinese patients with non-insulin-dependent diabetes mellitus.

doi:10.3901/jme.2000.11.080

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Article

The mutation of insulin receptor substrate-1 gene in Chinese patients with non-insulin-dependent diabetes mellitus.

Chinese medical journal - 1 Jan 2000

Zeng W, Peng J, Wan X, Chen S, Song H

Abstract excerpt

OBJECTIVE: To identify the relationship between mutation in the insulin receptor substrate-1 (IRS-1) gene and the incidence of non-insulin-dependent diabetes mellitus (NIDDM) in the Chinese population. METHODS: Samples were obtained from 68 Chinese patients with NIDDM and 68 control subjects. The +1700-(+)4437 bp fragment of the IRS-1 gene was screened by polymerase chain reaction (PCR)-single strand conformation...

Topics

Adult
Aged
Diabetes Mellitus, Type 2
Humans
Insulin Receptor Substrate Proteins
Middle Aged
Mutation
Phosphoproteins

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PMID: 11775217
DOI: 10.3901/jme.2000.11.080

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