Article
Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus.
Lancet (London, England) - 2 Oct 1993
Almind K, Bjørbaek C, Vestergaard H, Hansen T, Echwald S, Pedersen O
Abstract excerpt
Since relative or absolute insulin deficiency and insulin insensitivity are involved in the aetiology of non-insulin-dependent diabetes mellitus (NIDDM), we examined whether patients with NIDDM exhibit genetic variability in the coding region of insulin receptor substrate-1 (IRS-1), a candidate gene that is ubiquitous in insulin-sensitive and insulin-like growth factor 1 (IGF1) sensitive tissues, including those...
Topics
- Amino Acids
- Base Sequence
- Case-Control Studies
- Codon
- DNA
- Diabetes Mellitus, Type 2
- Female
- Humans
- Insulin Receptor Substrate Proteins
- Male
- Middle Aged