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TheH19Differentially Methylated Region Marks the Parental Origin of a Heterologous Locus without Gametic DNA Methylation

13 Apr 2004

Abstract excerpt

Igf2 and H19 are coordinately regulated imprinted genes physically linked on the distal end of mouse chromosome 7. Genetic analyses demonstrate that the differentially methylated region (DMR) upstream of the H19 gene is necessary for three distinct functions: transcriptional insulation of the maternal Igf2 allele, transcriptional silencing of paternal H19 allele, and marking of the parental origin of the two...

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Share to Epigenetics and DNA Methylation
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PMID: 15082756
DOI: 10.1128/mcb.24.9.3588-3595.2004

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TheH19Differentially Methylated Region Marks the Parental Origin of a Heterologous Locus without Gametic DNA MethylationPMID 15082756Read ↗

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