Article
Cytolytic activity of NK cell clones against acute childhood precursor-B-cell leukaemia is influenced by HLA class I expression on blasts and the differential KIR phenotype of NK clones.
Bone marrow transplantation - 1 Jun 2009
Feuchtinger T, Pfeiffer M, Pfaffle A, Teltschik H-M, Wernet D, Schumm M, Lotfi R, Handgretinger R, Lang P
Abstract excerpt
Relapse after allo-SCT in patients with acute leukaemia remains a major problem. A beneficial impact of alloreactive natural killer (NK) cells has been reported for myeloid malignancies, but has been questionable for B-lineage ALL. We analysed lysis of primary paediatric precursor-B-ALL blasts by 285 NK cell clones to investigate whether HLA class I expression on the blasts and phenotypic killer cell Ig-like...
Topics
- Histocompatibility Antigens Class I
- Humans
- Killer Cells, Natural
- Phenotype
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
- Receptors, KIR