Article
Overexpression of the tumour suppressor gene p53 is not implicated in neuroendocrine tumour carcinogenesis.
The Journal of pathology - 1 Apr 1995
Wang D G, Johnston C F, Anderson N, Sloan J M, Buchanan K D
Abstract excerpt
The tumorigenesis of neuroendocrine tumours remains poorly understood, although a minority, the familial multiple endocrine neoplasia (MEN 1 and MEN 2), are known to be of uncommon genetic origin. Mutation of the tumour suppressor gene, p53, is now known to be a common genetic alteration in about half of all types of non-endocrine cancers. In the present study, immunocytochemistry using the monoclonal anti-p53...
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