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Article

Overexpression of the tumour suppressor gene p53 is not implicated in neuroendocrine tumour carcinogenesis.

The Journal of pathology - 1 Apr 1995

Wang D G, Johnston C F, Anderson N, Sloan J M, Buchanan K D

Abstract excerpt

The tumorigenesis of neuroendocrine tumours remains poorly understood, although a minority, the familial multiple endocrine neoplasia (MEN 1 and MEN 2), are known to be of uncommon genetic origin. Mutation of the tumour suppressor gene, p53, is now known to be a common genetic alteration in about half of all types of non-endocrine cancers. In the present study, immunocytochemistry using the monoclonal anti-p53...

Topics

Antibodies, Monoclonal
Carcinoma, Small Cell
Cell Transformation, Neoplastic
Fluorescent Antibody Technique
Gene Expression
Genes, p53
Humans
Lung Neoplasms
Mutation
Neoplasm Proteins
Neuroendocrine Tumors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Thyroid Neoplasms

Source

Identifiers

PMID: 7790993
DOI: 10.1002/path.1711750406

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7790993-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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