Analysis of K-ras, N-ras, H-ras, and p53 in lung neuroendocrine neoplasms.

doi:10.1097/00019606-199906000-00003

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Article

Analysis of K-ras, N-ras, H-ras, and p53 in lung neuroendocrine neoplasms.

Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Jun 1999

Couce M E, Bautista D, Costa J, Carter D

Abstract excerpt

This study screened 11 samples of typical carcinoid (TC), 4 samples of atypical carcinoid (AC), 1 sample of large cell neuroendocrine carcinoma (LCNEC), and four metastases for point mutations in exons 5 to 8 of the p53 gene, and exons 1 and 2 of the K-ras. H-ras, and N-ras genes using polymerase chain reaction (PCR)-single-strand conformation polymorphism (SSCP) and direct sequencing and by immunohistochemistry...

Topics

Adult
Aged
Alleles
DNA Mutational Analysis
Exons
Female
Genes, ras
Humans
Immunohistochemistry
Lung Neoplasms
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation, Missense

Neuroendocrine Tumors

Point Mutation

Polymerase Chain Reaction

Polymorphism, Genetic

Polymorphism, Single-Stranded Conformational

Source

Open in PubMed

Identifiers

PMID: 10475381
DOI: 10.1097/00019606-199906000-00003

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