Article
p53 Protein accumulates in Cushings adenomas and invasive non-functional adenomas.
The Journal of clinical endocrinology and metabolism - 1 Nov 1994
Buckley N, Bates A S, Broome J C, Strange R C, Perrett C W, Burke C W, Clayton R N
Abstract excerpt
The p53 protein, a negative regulator of cell growth, plays an important role in the pathogenesis of many human tumours following gene mutation and/or deletion. We screened a large number of sporadic pituitary tumours for p53 protein accumulation suggestive of gene mutation. Samples were divided into benign adenomas (n = 95) and invasive tumours with local or distant invasion (n = 26). All main tumour classes...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.