Article
p53 gene mutations in pituitary adenomas: rare events.
Clinical endocrinology - 1 Dec 1994
Levy A, Hall L, Yeudall W A, Lightman S L
Abstract excerpt
OBJECTIVE: Occult pituitary adenomas are said to occur in up to 20% of random autopsy examinations, yet the only oncogene known to be associated with pituitary adenomas, gsp, is found in only 40% of somatotrophinomas, a subtype that accounts for a minority of pituitary tumours. Mutations of the p53 tumour suppressor gene are thought to be involved in the pathogenesis of as many as 50% of all human cancers,...
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