Article
Absence of p53 gene mutation and infrequent overexpression of p53 protein in hepatoblastoma.
The Journal of pathology - 1 Jul 1995
Chen T C, Hsieh L L, Kuo T T
Abstract excerpt
Ten cases of hepatoblastoma were studied for overexpression of p53 protein by immunohistochemistry and for possible p53 gene mutation by single strand conformation polymorphism (SSCP) analysis and direct DNA sequencing of the polymerase chain reaction products. Only one case of the macrotrabecular type at stage IV showed overexpression of p53 protein. No DNA mobility shift was found in any of these cases studied...
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