Absence of p53 gene mutation and infrequent overexpression of p53 protein in hepatoblastoma.

doi:10.1002/path.1711760306

Back to search

Article

Absence of p53 gene mutation and infrequent overexpression of p53 protein in hepatoblastoma.

The Journal of pathology - 1 Jul 1995

Chen T C, Hsieh L L, Kuo T T

Abstract excerpt

Ten cases of hepatoblastoma were studied for overexpression of p53 protein by immunohistochemistry and for possible p53 gene mutation by single strand conformation polymorphism (SSCP) analysis and direct DNA sequencing of the polymerase chain reaction products. Only one case of the macrotrabecula...

Topics

Base Sequence
Gene Expression
Genes, p53
Hepatoblastoma
Humans
Immunoenzyme Techniques
Liver Neoplasms
Molecular Sequence Data
Mutation
Neoplasm Proteins
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Tumor Suppressor Protein p53

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.