Article
Nuclear overexpression of p53 protein does not correlate with gene mutation in primary peritoneal carcinoma.
Human pathology - 1 Sept 1997
Marchenko N D, Moll U M
Abstract excerpt
Primary peritoneal carcinoma (PPC) is an aggressive malignancy of the female coelomic epithelium. Previously we had analyzed 29 cases of PPC for p53 protein accumulation by immunocytochemistry. P53 was overexpressed in 83% (24 of 29) of PPCs, including 21 tumors with diffuse intense staining of 1...
Topics
- Adenocarcinoma, Clear Cell
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Papillary
- Cell Nucleus
- Female
- Genes, p53
- Humans
- Immunohistochemistry
- Middle Aged
- Mixed Tumor, Mullerian
- Mutation
- Peritoneal Neoplasms
- Polymorphism, Single-Stranded Conformational
- Tumor Suppressor Protein p53