Article
Analysis of protein expression and gene mutation of c-kit in colorectal neuroendocrine carcinomas.
The American journal of surgical pathology - 1 Dec 2003
Akintola-Ogunremi Olaronke, Pfeifer John D, Tan Benjamin R, Yan Yan, Zhu Xiaopei, Hart John, Goldblum John R, Burgart Lawrence, Lauwers Gregory Y, Montgomery Elizabeth, Lewin David, Washington Kay, Bronner Mary, Xiao Shu-Yuan, Greenson Joel K, Lamps Laura, Lazenby Audrey, Wang Hanlin L
Abstract excerpt
Primary neuroendocrine carcinomas of the colon are rare but highly aggressive malignancies. The recent observations that c-kit protooncogene, a tyrosine kinase, is overexpressed in a subset of small cell lung cancer and that selective kinase inhibitors block the in vitro growth of small cell lung cancer cell lines prompted us to investigate the expression and mutation status of the c-kit gene in colorectal...
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