Article
Studies of the inheritance of human ribosomal DNA variants detected in two-dimensional separations of genomic restriction fragments.
Genetics - 1 Sept 1996
Kuick R, Asakawa J, Neel J V, Kodaira M, Satoh C, Thoraval D, Gonzalez I L, Hanash S M
Abstract excerpt
We have investigated the variation in human ribosomal DNA repeat units as revealed in two-dimensional electrophoretic separates of genomic restriction fragments that were end-labeled at NotI cleavage sites. The transcribed portion of the ribosomal DNA results in approximately 20 labeled fragments visible on each gel as multicopy spots. We have mapped these spots to the sequences responsible for their appearance...
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