Two-dimensional DNA typing: A cost-effective way of analyzing complex mixtures of DNA fragments for sequence variations.

doi:10.1007/BF02779021

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Article

Two-dimensional DNA typing: A cost-effective way of analyzing complex mixtures of DNA fragments for sequence variations.

Molecular biotechnology - 1 Dec 1995

Vijg J

Abstract excerpt

By two-dimensional (2D) DNA typing, multiple DNA fragments can be analyzed in parallel for all possible sequence variations. The method involves electrophoretic separation in polyacrylamide gels, first by size and subsequently on the basis of basepair sequence in a denaturing gradient. The system...

Topics

Cost-Benefit Analysis
DNA Fingerprinting
DNA, Viral
Electrophoresis, Gel, Two-Dimensional
Gene Amplification
Genetic Testing
Genetic Variation
Genome
Genotype
Humans
Image Processing, Computer-Assisted
Mutation
Reproducibility of Results
Sequence Analysis, DNA

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