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Article

sli-1, a negative regulator of let-23-mediated signaling in C. elegans.

Genetics - 1 Apr 1995

Jongeward G D, Clandinin T R, Sternberg P W

Abstract excerpt

By screening for suppressors of hypomorphic mutations of let-23, a receptor tyrosine kinase necessary for vulval induction in Caenorhabditis elegans, we recovered > or = 12 mutations defining the sli-1 (suppressor of lineage defect) locus. sli-1 mutations suppress four of five phenotypes associated with hypomorphic alleles of let-23 but do not suppress let-23 null alleles. Thus, a sli-1 mutation does not bypass...

Topics

Alleles
Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Dosage Compensation, Genetic
ErbB Receptors
Female
Genes, Suppressor
Helminth Proteins
Male
Phenotype
Signal Transduction

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Vulva

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Identifiers

PMID: 7789760
DOI: 10.1093/genetics/139.4.1553
PMCID: PMC1206484

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7789760-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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