Article
sli-1, a negative regulator of let-23-mediated signaling in C. elegans.
Genetics - 1 Apr 1995
Jongeward G D, Clandinin T R, Sternberg P W
Abstract excerpt
By screening for suppressors of hypomorphic mutations of let-23, a receptor tyrosine kinase necessary for vulval induction in Caenorhabditis elegans, we recovered > or = 12 mutations defining the sli-1 (suppressor of lineage defect) locus. sli-1 mutations suppress four of five phenotypes associated with hypomorphic alleles of let-23 but do not suppress let-23 null alleles. Thus, a sli-1 mutation does not bypass...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.