Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Requirements of multiple domains of SLI-1, a Caenorhabditis elegans homologue of c-Cbl, and an inhibitory tyrosine in LET-23 in regulating vulval differentiation.

Molecular biology of the cell - 1 Nov 2000

Yoon C H, Chang C, Hopper N A, Lesa G M, Sternberg P W

Abstract excerpt

SLI-1, a Caenorhabditis elegans homologue of the proto-oncogene product c-Cbl, is a negative regulator of LET-23-mediated vulval differentiation. Lack of SLI-1 activity can compensate for decreased function of the LET-23 epidermal growth factor receptor, the SEM-5 adaptor, but not the LET-60 RAS, suggesting that SLI-1 acts before RAS activation. SLI-1 and c-Cbl comprise an N-terminal region (termed SLI-1:N/Cbl-N,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Helminth Proteins
Share to Proto-Oncogene Proteins c-cbl

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to ras GTPase-Activating Proteins

Share to Receptor Protein-Tyrosine Kinases

Share to src Homology Domains

Share to Suppression, Genetic

Share to Tyrosine

Source

Open in PubMed Open full text

Identifiers

PMID: 11071924
DOI: 10.1091/mbc.11.11.4019
PMCID: PMC15054

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Requirements of multiple domains of SLI-1, a Caenorhabditis elegans homologue of c-Cbl, and an inhibitory tyrosine in LET-23 in regulating vulval differentiation.PMID 11071924Read ↗

Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl.Semantic proximity Read ↗

EGF receptor binding and transformation by v-cbl is ablated by the introduction of a loss-of-function mutation from the Caenorhabditis elegans sli-1 gene.Semantic proximity Read ↗

sli-1, a negative regulator of let-23-mediated signaling in C. elegans.Semantic proximity Read ↗

Caenorhabditis elegans SOS-1 is necessary for multiple RAS-mediated developmental signals.Semantic proximity Read ↗

Coordinated regulation of intestinal functions in C. elegans by LIN-35/Rb and SLR-2.Semantic proximity Read ↗

The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans.Semantic proximity Read ↗

A point mutation in the extracellular domain activates LET-23, the Caenorhabditis elegans epidermal growth factor receptor homolog.Semantic proximity Read ↗

LIN-12/Notch trafficking and regulation of DSL ligand activity during vulval induction in Caenorhabditis elegans.Semantic proximity Read ↗

An activating mutation in sos-1 identifies its Dbl domain as a critical inhibitor of the epidermal growth factor receptor pathway during Caenorhabditis elegans vulval development.Semantic proximity Read ↗

The Caenorhabditis elegans Skp1-related gene family: diverse functions in cell proliferation, morphogenesis, and meiosis.Semantic proximity Read ↗

A Drosophila analogue of v-Cbl is a dominant-negative oncoprotein in vivo.Semantic proximity Read ↗

Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.