Article
ARK-1 inhibits EGFR signaling in C. elegans.
Molecular cell - 1 Jul 2000
Hopper N A, Lee J, Sternberg P W
Abstract excerpt
A screen for synthetic enhancers of sli-1 identified ark-1 (forAck-related tyrosine kinase), a novel inhibitor of let-23 EGFR signaling in C. elegans. An ark-1 mutation synergizes with mutations in other negative regulators of let-23, resulting in increased RAS signaling. Genetic analysis suggests that ARK-1 acts upstream of RAS and is dependent upon SEM-5. ARK-1 inhibits LET-23-mediated ovulation, a...
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