Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl.

doi:10.1126/science.7652556

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Article

Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl.

Science (New York, N.Y.) - 25 Aug 1995

Yoon C H, Lee J, Jongeward G D, Sternberg P W

Abstract excerpt

Vulval induction during Caenorhabditis elegans development is mediated by LET-23, a homolog of the mammalian epidermal growth factor receptor tyrosine kinase. The sli-1 gene is a negative regulator of LET-23 and is shown here to encode a protein similar to c-Cbl, a mammalian proto-oncoprotein. SLI-1 and c-Cbl share approximately 55 percent amino acid identity over a stretch of 390 residues, which includes a C3HC4...

Topics

Amino Acid Sequence
Animals
Base Sequence
Binding Sites
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Conserved Sequence
DNA, Complementary
ErbB Receptors
Female
Genes, Helminth

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Regulator

Helminth Proteins

Humans

Molecular Sequence Data

Mutation

Proto-Oncogene Mas

Proto-Oncogene Proteins

Source

Open in PubMed

Identifiers

PMID: 7652556
DOI: 10.1126/science.7652556

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7652556-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl.PMID 7652556Read ↗

Requirements of multiple domains of SLI-1, a Caenorhabditis elegans homologue of c-Cbl, and an inhibitory tyrosine in LET-23 in regulating vulval differentiation.Semantic proximity Read ↗

EGF receptor binding and transformation by v-cbl is ablated by the introduction of a loss-of-function mutation from the Caenorhabditis elegans sli-1 gene.Semantic proximity Read ↗

sli-1, a negative regulator of let-23-mediated signaling in C. elegans.Semantic proximity Read ↗

The Caenorhabditis elegans Skp1-related gene family: diverse functions in cell proliferation, morphogenesis, and meiosis.Semantic proximity Read ↗

An activating mutation in sos-1 identifies its Dbl domain as a critical inhibitor of the epidermal growth factor receptor pathway during Caenorhabditis elegans vulval development.Semantic proximity Read ↗

sli-3 negatively regulates the LET-23/epidermal growth factor receptor-mediated vulval induction pathway in Caenorhabditis elegans.Semantic proximity Read ↗

A point mutation in the extracellular domain activates LET-23, the Caenorhabditis elegans epidermal growth factor receptor homolog.Semantic proximity Read ↗

Mutations in the Caenorhabditis elegans let-23 EGFR-like gene define elements important for cell-type specificity and function.Semantic proximity Read ↗

cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.Semantic proximity Read ↗

Caenorhabditis elegans SOS-1 is necessary for multiple RAS-mediated developmental signals.Semantic proximity Read ↗

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C. elegans CAND-1 regulates cullin neddylation, cell proliferation and morphogenesis in specific tissues.Semantic proximity Read ↗

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