Allele-specific suppressors of lin-1(R175Opal) identify functions of MOC-3 and DPH-3 in tRNA modification complexes in Caenorhabditis elegans.

doi:10.1534/genetics.110.118406

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Article

Allele-specific suppressors of lin-1(R175Opal) identify functions of MOC-3 and DPH-3 in tRNA modification complexes in Caenorhabditis elegans.

Genetics - 1 Aug 2010

Kim Sunhong, Johnson Wade, Chen Changchun, Sewell Aileen K, Byström Anders S, Han Min

Abstract excerpt

The elongator (ELP) complex consisting of Elp1-6p has been indicated to play roles in multiple cellular processes. In yeast, the ELP complex has been shown to genetically interact with Uba4p/Urm1p and Kti11-13p for a function in tRNA modification. Through a Caenorhabditis elegans genetic suppressor screen and positional cloning, we discovered that loss-of-function mutations of moc-3 and dph-3, orthologs of the...

Topics

Amino Acid Sequence
Animals
Animals, Genetically Modified
Blotting, Western
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Gene Expression Regulation, Developmental
Green Fluorescent Proteins
Larva
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Phenotype

RNA Interference

RNA, Transfer

Reverse Transcriptase Polymerase Chain Reaction

Sequence Homology, Amino Acid

Temperature

Transcription Factors

Source

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Identifiers

PMID: 20479142
DOI: 10.1534/genetics.110.118406
PMCID: PMC2927752

Genes

URM1

Provenance

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