Article
MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction.
Cell - 15 May 1998
Tan P B, Lackner M R, Kim S K
Abstract excerpt
The let-23 receptor/mpk-1 MAP kinase signaling pathway induces the vulva in C. elegans. We show that MPK-1 directly regulates both the LIN-31 winged-helix and the LIN-1 Ets transcription factors to specify the vulval cell fate. lin-31 and lin-1 act genetically downstream of mpk-1, and both protei...
Topics
- 3T3 Cells
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- DNA-Binding Proteins
- Embryonic Induction
- ErbB Receptors
- Female
- Gene Expression Regulation, Developmental
- Helminth Proteins
- Herpes Simplex Virus Protein Vmw65
- Mice
- Mitogen-Activated Protein Kinase 1
- Mutation
- Organ Specificity
- Phosphorylation
- Protein Serine-Threonine Kinases
- Recombinant Fusion Proteins