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Article

Biological activity of human N-ras and K-ras genes containing the Asn17 dominant negative mutation.

Oncology research - 1 Jan 1994

Kaplan J B

Abstract excerpt

Substitution of asparagine for serine at position 17 of human H-ras results in an impaired GTP-binding activity, causing the mutant Ras protein to be locked in a constitutively inactive GDP-bound state. Expression of this mutant in NIH 3T3 cells inhibits cell proliferation by blocking endogenous ras function. Plasmids that encode the analogous dominant negative mutation at position 17 in human N- and K-ras were...

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PMID: 7787254

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Biological activity of human N-ras and K-ras genes containing the Asn17 dominant negative mutation.PMID 7787254Read ↗

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