[Inhibition of ras-dependent transformation by using dominant negative ras mutant N116Y].

Abstract excerpt

Ras p21s are known as molecular switch for signal transduction pathways. They act as intracellular signal transducers of extracellular signals for growth and differentiation. Ras activities are regulated by the rotation between active GTP-bound form and inactive GDP-bound form. This cycle is regulated by the GDP/GTP exchange reaction and intrinsic GTPase activity of ras p21. The N116Y, v-H-ras mutant substituted...

Topics

• Animals
• Cell Transformation, Neoplastic
• Cells, Cultured
• GTP Phosphohydrolases
• Gene Expression Regulation, Neoplastic
• Genes, ras
• Guanosine Diphosphate
• Guanosine Triphosphate
• Humans
• Mice
• Mutation