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Article

Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells.

Molecular and cellular biology - 1 Oct 1990

Szeberényi J, Cai H, Cooper G M

Abstract excerpt

A dominant inhibitory mutation of Ha-ras which changes Ser-17 to Asn-17 in the gene product p21 [p21 (Asn-17)Ha-ras] has been used to investigate the role of ras in neuronal differentiation of PC12 cells. The growth of PC12 cells, in contrast to NIH 3T3 cells, was not inhibited by p21(Asn-17)Ha-ras expression. However, PC12 cells expressing the mutant Ha-ras protein showed a marked inhibition of morphological...

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Identifiers

PMID: 2118994
DOI: 10.1128/mcb.10.10.5324-5332.1990
PMCID: PMC361225

Genes

NGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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