Article
Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells.
Molecular and cellular biology - 1 Oct 1990
Szeberényi J, Cai H, Cooper G M
Abstract excerpt
A dominant inhibitory mutation of Ha-ras which changes Ser-17 to Asn-17 in the gene product p21 [p21 (Asn-17)Ha-ras] has been used to investigate the role of ras in neuronal differentiation of PC12 cells. The growth of PC12 cells, in contrast to NIH 3T3 cells, was not inhibited by p21(Asn-17)Ha-r...
Topics
- Adrenal Gland Neoplasms
- Animals
- Cell Differentiation
- Cell Division
- DNA-Binding Proteins
- Fibroblast Growth Factors
- Gene Expression Regulation
- Genes, Dominant
- Matrix Metalloproteinase 3
- Metalloendopeptidases
- Mutation
- Nerve Growth Factors
- Neurons
- Oncogene Protein p21(ras)
- Pheochromocytoma
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-fos
- Proto-Oncogene Proteins c-jun