Article
Effect of a dominant inhibitory Ha-ras mutation on mitogenic signal transduction in NIH 3T3 cells.
Molecular and cellular biology - 1 Oct 1990
Cai H, Szeberényi J, Cooper G M
Abstract excerpt
We used a dominant inhibitory mutation of c-Ha-ras which changes Ser-17 to Asn-17 in the gene product p21 [p21(Asn-17)Ha-ras] to investigate ras function in mitogenic signal transduction. An NIH 3T3 cell line [NIH(M17)] was isolated that displayed inducible expression of the mutant Ha-ras gene (H...
Topics
- Animals
- Cell Line
- DNA
- DNA-Binding Proteins
- Genes, Dominant
- Growth Substances
- Mice
- Mitogens
- Mutation
- Nuclear Proteins
- Oncogene Protein p21(ras)
- Oncogenes
- Protein Kinase C
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-fos
- Proto-Oncogene Proteins c-jun
- Proto-Oncogene Proteins c-myc
- Signal Transduction