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Article

Phenotyping and genotyping of S-mephenytoin hydroxylase (cytochrome P450 2C19) in a Shona population of Zimbabwe.

Clinical pharmacology and therapeutics - 1 Jun 1995

Masimirembwa C, Bertilsson L, Johansson I, Hasler J A, Ingelman-Sundberg M

Abstract excerpt

The S-mephenytoin hydroxylase has recently been identified as cytochrome P450 2C19 (CYP2C19). This enzyme metabolizes mephenytoin, diazepam, omeprazole, and citalopram and has been shown to be polymorphically distributed. One clinical implication of CYP2C19-dependent drug metabolism for persons w...

Topics

Adult
Aryl Hydrocarbon Hydroxylases
Base Sequence
Cytochrome P-450 CYP2C19
Cytochrome P-450 Enzyme System
Ethnicity
Genotype
Humans
Mixed Function Oxygenases
Molecular Sequence Data
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Zimbabwe

Source

Identifiers

PMID: 7781265
DOI: 10.1016/0009-9236(95)90228-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7781265-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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