Article
Analysis of the CYP2C19 polymorphism in a North-eastern Thai population.
Pharmacogenetics - 1 Apr 2002
Tassaneeyakul Wichittra, Tawalee Arporn, Tassaneeyakul Wongwiwat, Kukongviriyapan Veerapol, Blaisdell Joyce, Goldstein Joyce A, Gaysornsiri Dhanu
Abstract excerpt
CYP2C19 is a polymorphically expressed cytochrome P450 responsible for the metabolism of several clinically used drugs, including some barbiturates, diazepam, proguanil, propranolol and several proton pump inhibitors. Genetic polymorphism of this enzyme shows marked interracial differences, with the poor metabolizer (PM) phenotype representing 2-5% of Caucasian and 11-23% of Oriental populations. In the present...
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