Article
CYP2C9, CYP2C19, ABCB1 (MDR1) genetic polymorphisms and phenytoin metabolism in a Black Beninese population.
Pharmacogenetics and genomics - 1 Nov 2005
Allabi Aurel C, Gala Jean-Luc, Horsmans Yves
Abstract excerpt
The genetically polymorphic cytochrome P450 2C9 (CYP2C9) metabolizes many important drugs. Among them, phenytoin has been used as a probe to determine CYP2C9 phenotype by measuring the urinary excretion of its major metabolite, S-enantiomer of 5-(4-hydroxyphenyl)-5-phenylhydantoin (p-HPPH). Phenytoin pharmacokinetic is also dependent on the activity of CYP2C19 and p-glycoprotein (ABCB1). To determine the...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Adolescent
- Adult
- Aryl Hydrocarbon Hydroxylases
- Benin
- Black People
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 CYP2C9
- Female
- Genetic Variation
- Genetics, Population
- Genotype
- Haplotypes
- Humans
- Male
- Middle Aged
- Mixed Function Oxygenases
- Pharmacogenetics