Article
Genetic polymorphism of cytochrome P450 CYP2D6 in Zimbabwean population.
Pharmacogenetics - 1 Dec 1993
Masimirembwa C M, Johansson I, Hasler J A, Ingelman-Sundberg M
Abstract excerpt
The objective of this study was to determine the CYP2D6 genotype of a black Zimbabwean population. Genotyping was carried out using Eco RI and Xba I RFLP, and allele-specific PCR amplification. Of 114 Zimbabwean samples analysed, no individual homozygous for any of the defect allelic forms CYP2D6A, CYP2D6B or CYP2D6D or combinations thereof was found. The allele frequencies of the three defect genes were 0, 1.8...
Topics
- Base Sequence
- Black People
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- DNA Primers
- Genotype
- Humans
- Mixed Function Oxygenases
- Molecular Sequence Data
- Polymerase Chain Reaction
- Polymorphism, Genetic