Article
S-mephenytoin hydroxylation phenotype and CYP2C19 genotype among Ethiopians.
Pharmacogenetics - 1 Dec 1996
Persson I, Aklillu E, Rodrigues F, Bertilsson L, Ingelman-Sundberg M
Abstract excerpt
The polymorphic metabolism of S-mephenytoin and the distribution of two known deleterious mutant CYP2C19 alleles was determined among 114 healthy unrelated black Ethiopians. Six subjects (5.2%) were poor metabolizers (PMs) of S-mephenytoin. The frequencies of the defective CYP2C19*2 (CYP2C19m1) a...
Topics
- Alleles
- Aryl Hydrocarbon Hydroxylases
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 Enzyme System
- Ethiopia
- Female
- Gene Frequency
- Genotype
- Humans
- Male
- Mephenytoin
- Mixed Function Oxygenases
- Phenotype
- Polymorphism, Genetic