Evidence that poor metabolizers of (S)-mephenytoin could be identified by haplotypes of CYP2C19 in Japanese.

doi:10.1097/00008571-199606000-00011

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Article

Evidence that poor metabolizers of (S)-mephenytoin could be identified by haplotypes of CYP2C19 in Japanese.

Pharmacogenetics - 1 Jun 1996

Takakubo F, Kuwano A, Kondo I

Abstract excerpt

(S)-Mephenytoin is metabolized by CYP2C19. The purpose of this study was to examine availability of phenotyping of poor metabolizers (PMs) of (S)-mephenytoin by polymerase chain reaction (PCR)/restriction enzyme genotyping of CYP2C19 in a Japanese population. We genotyped 217 unrelated healthy Ja...

Topics

Adolescent
Adult
Alleles
Aryl Hydrocarbon Hydroxylases
Child
Child, Preschool
Cytochrome P-450 CYP2C19
Cytochrome P-450 Enzyme System
Female
Genotype
Haplotypes
Heterozygote
Homozygote
Humans
Infant
Japan
Male
Mephenytoin

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