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Article

Multiple genetic alterations in hamster pancreatic ductal adenocarcinomas.

Cancer research - 15 Jun 1995

Chang K W, Laconi S, Mangold K A, Hubchak S, Scarpelli D G

Abstract excerpt

Pancreatic ductal adenocarcinomas induced in the Syrian golden hamster (SGH) by N-nitrosobis(2-oxopropyl)amine share many similarities with the human disease, including mutations of the K-ras oncogene. In vitro carcinogenesis studies with immortal SGH pancreatic duct cells indicate that neoplastic transformation in this system can occur without mutational inactivation of p53 suppressor gene. In this study we...

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PMID: 7780969

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DCC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple genetic alterations in hamster pancreatic ductal adenocarcinomas.PMID 7780969Read ↗

Genomic p53 mutation in a chemically induced hamster pancreatic ductal adenocarcinoma.Semantic proximity Read ↗

K-ras and p53 mutations in hamster pancreatic ductal adenocarcinomas and cell lines.Semantic proximity Read ↗

In vitro carcinogenesis of hamster pancreatic duct cells: cellular and molecular alterations.Semantic proximity Read ↗

Mechanistic analysis of pancreatic ductal carcinogenesis in hamsters.Semantic proximity Read ↗

K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster.Semantic proximity Read ↗

Pancreatic ductal adenocarcinomas induced in Syrian hamsters by N-nitrosobis(2-oxopropyl)amine contain a c-Ki-ras oncogene with a point-mutated codon 12.Semantic proximity Read ↗

Frequent p16INK4A/CDKN2A alterations in chemically induced Syrian golden hamster pancreatic tumors.Semantic proximity Read ↗

High yields of K-ras mutations in intraductal papillary mucinous tumors and invasive adenocarcinomas induced by N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine in the pancreas of female Syrian hamsters.Semantic proximity Read ↗

Alterations in the Smad4 gene in hamster pancreatic duct adenocarcinomas and established cell lines.Semantic proximity Read ↗

K-ras gene mutation in early ductal lesions induced in a rapid production model for pancreatic carcinomas in Syrian hamsters.Semantic proximity Read ↗

Mutational activation of K-ras in nonneoplastic exocrine pancreatic lesions in relation to cigarette smoking statusSemantic proximity Read ↗

K-ras gene mutations in intrahepatic bile duct tumors of Syrian golden hamsters.Semantic proximity Read ↗

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