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Article

Intragenomic complementation of a 3AB mutant in dicistronic polioviruses.

Virology - 1 Jun 1995

Cao X, Wimmer E

Abstract excerpt

We report the construction of a poliovirus genome [pPVM-VPg(3F4A)] harboring a double mutation in VPg. This mutant, in which the tyrosine and the threonine at residues 3 and 4 of the VPg region were replaced by phenylalanine and alanine, respectively, is lethal, that is, all RNA synthesis was abolished and no revertants could be isolated. Using the properties of dicistronic polioviruses (with the general genotype...

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Identifiers

PMID: 7778266
DOI: 10.1006/viro.1995.1263

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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